The selective activation of prodrug s in tumor tissues by exogenous enzyme s for cancer therapy can be accomplished by several ways including gene directed enzyme prodrug therapy gdept virus directed enzyme prodrug therapy vdept and antibody directed enzyme prodrug therapy adept the central part of enzyme prodrug cancer therapy is to . By exogenous enzymes for cancer therapy can be accom plished by several ways including gene directed enzyme prodrug therapy gdept virus directed enzyme prodrug therapy vdept and antibody directed enzyme prodrug therapy adept the central part of enzyme prodrug can cer therapy is to deliver drug activating enzyme gene or. Strategies for enzyme prodrug cancer therapy prodrugs of anthracyclines for use in antibody directed enzyme prodrug therapy enhancement of antibody directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent molecular and functional characterization of a fusion protein suited for tumor specific prodrug activation. Antibody directed enzyme prodrug therapy adept directly addresses the major problem in cancer chemotherapy its lack of selectivity antibody delivery combined with the amplification provided by the enzymatic activation of prodrugs enables selection to be made between tumour and normal tissue